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Apreszine 25

Apreszine 25

hydralazine

Manufacturer:

Community Pharm PCL

Distributor:

Community Pharm PCL

Marketer:

Community Pharm PCL
Concise Prescribing Info
Contents
Hydralazine HCl
Indications/Uses
Adjunct to other antihypertensive in the management of moderate to severe HTN.
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Dosage/Direction for Use
Adult Initially 25 mg bid for the 1st 2-4 days. Increase to 25 mg qid for balance of the 1st wk. Dosage titration: 50 mg qid from 2nd wk. Maintenance dose: Adjust dose to lowest effective level. Up to 300 mg daily in resistant patients.
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Overdosage
View Apreszine 25 overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. CAD; mitral valvular rheumatic heart disease. Patients w/ severe tachycardia, dissecting aortic aneurysm, heart failure w/ high cardiac output, cor pulmonale, or myocardial insufficiency due to mechanical obstruction eg, aortic or mitral stenosis or constrictive. Idiopathic SLE & related disorders.
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Special Precautions
Discontinue therapy if blood dyscrasias (eg, Hb & RBC count reduction, leucopenia, agranulocytosis, purpura) occur. Drug-induced lupus-like syndrome including glomerulonephritis in patients receiving higher doses. Postural hypotension. Patients w/ CVA & suspected CAD, producing myocardial stimulation causing angina attacks & ECG changes of myocardial ischemia. Increased pulmonary artery pressure in patients w/ mitral valvular disease. Initiate pyridoxine therapy w/ onset of peripheral neuritis (eg, paresthesia, numbness, tingling). Advanced renal impairment. Not to be used during pregnancy. Lactation.
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Adverse Reactions
Headache, anorexia, nausea, vomiting, diarrhea, palpitations, tachycardia, angina pectoris.
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Drug Interactions
May increase levels/effects of amifostine, 2nd generation antipsychotics, bromperidol, duloxetine, hypotension associated agents, levodopa, nitroprusside, pholcodine. Increased levels/effects w/ alfuzosin, barbiturates, benperidol, brigatinib, topical brimonidine, dapoxetine, diazoxide, herbs (hypotensive properties), lormetazepam, molsidomine, naftopidil, nicergoline, nicorandil, obinutuzumab, pentoxifylline, phosphodiesterase-5 inhibitors, prostacyclin analogues, quinagolide. Decreased levels/effects w/ amphetamines, brigatinib, bromperidol, herbs (hypertensive properties), methylphenidate, NSAIDs, yohimbine.
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Storage
View Apreszine 25 storage conditions for details to ensure optimal shelf-life.
Description
View Apreszine 25 description for details of the chemical structure and excipients (inactive components).
Action
View Apreszine 25 mechanism of action for pharmacodynamics and pharmacokinetics details.
MIMS Class
Other Antihypertensives
ATC Classification
C02DB02 - hydralazine ; Belongs to the class of hydrazinophthalazine derivatives. Used in the treatment of hypertension.
Presentation/Packing
Form
Apreszine 25 FC tab 25 mg
Packing/Price
50 × 10's
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